-
Human lactation research started (Neville/Neifert)
-
Human milk nutrition research started (Krebs/Hambidge)
1980's
-
Cellular and metabolic regulation of milk lipid secretion started (McManaman/Neville/Anderson)
-
Transcytosis mechanisms identified (Monks/Neville)
-
First use of proteomics to define milk lipid secretion (McManaman)
-
Phagocytotic function of mammary epithelial cells identified (Monks/Fadok)
-
First use of RNA expression profiling to define mammary gland functional development (Neville/Rudolph/McManaman)
2000's
-
Molecular mechanisms of milk lipid secretion identified by mouse genetics (McManaman/Monks)
-
First use of single cell RNA sequencing to identify human milk cellular composition (Martin Carli/Rudolph/ Monks/MacLean/McManaman)
-
Identification of cellular functions in human milk fat globules (Martin Carli /Monks/McManaman)
-
Lactation initiation is shown to depend on milk lipid secretion (Monks/McManaman)
-
Mammary gland structure defined by AI (Monks)
2020's
1970's
Mammary gland ion transport studies started (Neville)
1990's
-
Molecular mechanisms of milk lipid secretion started (Neville/Neifert)
-
Regulation of mammary gland tight junctions identified (Neville)
2010's
-
Role of insulin signaling in mammary gland differentiation identified (Neville/Maclean)
-
Role of molecular structure in milk lipid secretion identified (McManaman)
-
Identification of diet and obesity effects on lactation (McManaman/MacLean)
-
First use of high-resolution 3D electron tomography to demonstrate that milk lipids originate from novel endoplasmic reticulum domains (McManaman/Howell)
Pictures throughout the years